This week, the San Francisco Department of Public Health released the most recent HIV epidemiology annual report—a comprehensive summary of current HIV data and trends in San Francisco. Although the number of HIV infections happening every year continues to decline, disparities remain among African Americans, Latinos, men who have sex with men, trans women, people experiencing homelessness and people who use substances in our city. As San Francisco moves toward its Getting to Zero goals, these lingering disparities highlight the need for continued investment in programs and resources that target our city’s most marginalized communities.